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Arachidonic Acid

506-32-1

CH3(CH2)4(CH=CHCH2)4CH2CH2CO2H

304.47

ARA,cis,cis,cis,cis-5,8,11,14-Eicosatetraenoic acid, Eicosa-5Z,8Z,11Z,14Z-tetraenoic acid, Immunocytophyte;

40% oil; 10% powder

Arachidonic Acid
ProductSpecifications
Arachidonic Acid10% powder
Arachidonic Acid40% oil

Arachidonic Acid Properties

Melting point:
−49 °C(lit.)
Boiling point:
169-171 °C0.15 mm Hg(lit.)
Density 
0.922 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.4872(lit.)
Flash point:
>230 °F
storage temp. 
−20°C
solubility 
ethanol: ≥10 mg/mL
form 
oil
color 
colorless to light yellow
Water Solubility 
PRACTICALLY INSOLUBLE
Merck 
14,765

Description

Arachidonic acid belongs to a kind of polyunsaturated omega-6 fatty acid, which is highly biologically relevant. It is abundantly distributed in brain, muscles and liver. It is the precursor for all prostaglandins, thromboxanes, and leukotrienes. Most cellular arachidonic acid is esterified in the membrane phospholipids. It is an important second messenger of cellular signalling participating in the regulation of signaling enzymes including PLC-γ, PLC-δ, and PKC-α, -β, and -γ isoforms. In addition, arachidonic acid acts as key inflammatory intermediate as well as avasodilator. Generally, the body can synthesize the arachidonic acid through linoleic acid. However, upon linoleic acid deficiency, it is necessary to supplement arachidonic acid from the diets. Food sources of arachidonic acid include meat, eggs and some fishes. Alternatively, we can also have arachidonic acid supplements.

References

http://www.fitday.com/fitness-articles/nutrition/healthy-eating/what-is-arachidonic-acid.html
https://en.wikipedia.org/wiki/Arachidonic_acid
https://www.caymanchem.com/product/90010

Chemical Properties

liquid

Uses

An unsaturated omega-6 fatty acid constituent of the phospholipids of cell membranes

Uses

Arachidonic Acid is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic Acid occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and Arachidonic Acid is also a constituent of animal phosphatides.

Definition

ChEBI: A long-chain fatty acid that is a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14.

Biological Activity

Endogenous free fatty acid released from phospholipids by phospholipase A 2 . Important cellular signaling mediator and precursor of eicosanoids. Metabolized by lipoxygenases, cyclooxygenases and cytochrome P450 monooxygenases.

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