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L-Arginine

74-79-3

H2NC(=NH)NH(CH2)3CH(NH2)CO2H

174.20

(S)-2-Amino-5-guanidinopentanoic acid

FCC/USP/AJI/EP

L Arginine
ProductSpecifications
L-ArginineFCC
L-ArginineUSP
L-ArginineAJI
L-ArginineEP

L-Arginine Properties

L(+)-Arginine Chemical Properties,Uses,Production

Indications and Usage

Odorless, slightly bitter. Easily soluble in water (solubility in 0℃ water is 83g/L, solubility in 50℃ water is 400g/L),very slightly soluble in ethanol, insoluble in ether; pI6.0; loses its 2-molecule water crystal when heated to 105℃, darkens in color at 230℃, disintegrates at 244℃; its aqueous solution has maximum absorption at 205nm (1gε3.28).
L-Arginine is an encoding amino acid in protein synthesis and is one of the 8 essential amino acids in the human body. The body needs it for many different functions. Taking L-Arginine supplements can treat certain diseases such as congestive heart failure and cystitis. L-Arginine can also act as seasoning for nutrient supplements and food additives. L-Arginine can undergo a heat reaction with sugar (amino-carbonyl reaction) to obtain a unique fragrance, GB 2760-2001, an approved food spice. As an amino acid drug, L-Arginine can be used as pharmaceutical raw material and is an important ingredient in amino acid infusions and integrated amino acid preparations. It is also a crucial amino acid in maintaining infant growth and maturation.

Mechanisms of Action

L-Arginine can stimulate the human body to release certain chemicals such as insulin and human growth hormone. It can also clear ammonia in the body and promote the healing of wounds. The human body also needs it to produce sarcosine. Decomposing L-Arginine produces nitric oxide, which can expand blood vessels and increase blood flow. L-Arginine is an intermediate metabolite in the orthinine cycle and promotes the conversion of ammonia to urea, thus lowering the blood concentration of ammonia. L-Arginine is also an important part of sperm protein and can promote spermatogenesis and provide energy for sperm movement. Additionally, intravenous arginine can stimulate the pituitary to release growth hormone and can be used to test pituitary functions.

Adverse reactions

Abdominal pain, diarrhea, gout and bloating. There may also be increased severity in herpes breakouts and increased effects of antihypertensive drugs, resulting in a lower blood pressure than expected, which may cause hypertensive patients to experience dizziness and fainting.

Toxicity Level

Moderate

Acute Toxicity

Reference data: abdominal cavity – large rat LD50: 3793 mg/kg.

Flammability Characteristics

Flammable. Burning produces toxic nitrogen oxide smoke.

Handling

Store in ventilated, cool and dry area.

Extinguishers

Dry powder, foam, sand, carbon dioxide, water mist.

Chemical Properties

White crystalline powder

Definition

ChEBI: An L-alpha-amino acid that is the L-isomer of arginine.

L(+)-Arginine Preparation Products And Raw materials

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