groside V; Mogroside Ⅴ; Mogroside V; Mogrosides V; MOGROSIDE V(P); Mogroside V ,98%; Luo Han Guo P.E.; Luo Han Guo PE80%; Momordica Extract; Momordica grosvenori
3%, 20%, 30%, 40%, 50%, 55% Mogroside V
|Luo Han Guo Extracts||3% Mogroside V|
|Luo Han Guo Extracts||20% Mogroside V|
|Luo Han Guo Extracts||30% Mogroside V|
|Luo Han Guo Extracts||40% Mogroside V|
|Luo Han Guo Extracts||50% Mogroside V|
|Luo Han Guo Extracts||55% Mogroside V|
Mogroside V is a natural cucurbitane glycoside which has a sweetening strength of 250 times that of sucrose and is derived from mature fruit of luo-han-guo (Siraitia grosvenorii, monk fruit).
Mogroside V possesses tumor growth inhibitory activity in in vitro and in vivo models of pancreatic cancer by promoting apoptosis and cell cycle arrest of pancreatic cancer cells (PANC-1 cells),which may in part be mediated through regulating the STAT3 signaling pathway. Mogroside V inhibits the proliferation of pancreatic cancer cells and other tumor cell types in a dose- and time-dependent manner, and shows very little cytotoxicity against the non-tumorigenic epithelial cell line L02. Mogroside V inhibits the downstream targets of the STAT3 pathway that promote cell proliferation (CCND1, CCNE1 and CDK2),while also upregulating cell cycle inhibitors (CDKN1A and CDKN1B)
Mogroside V treatment promotes apoptosis of pancreatic cancer cells in the xenograft tumors. Mogroside V treatment significantly reduces the expression of CD31-labeled blood vessels and of the pro-angiogenic factor vascular endothelial growth factor in the xenografts, indicating that mogroside V might limit the growth of pancreatic tumors by inhibiting angiogenesis and reducing vascular density. Mogroside V treatment inhibits tumor cell growth, induces apoptosis and causes tumor regression
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