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Luo Han Guo Extracts

88901-36-4

C60H102O29

1287.44

groside V; Mogroside Ⅴ; Mogroside V; Mogrosides V; MOGROSIDE V(P); Mogroside V ,98%; Luo Han Guo P.E.; Luo Han Guo PE80%; Momordica Extract; Momordica grosvenori

3%, 20%, 30%, 40%, 50%, 55% Mogroside V

ProductSpecifications
Luo Han Guo Extracts3% Mogroside V
Luo Han Guo Extracts20% Mogroside V
Luo Han Guo Extracts30% Mogroside V
Luo Han Guo Extracts40% Mogroside V
Luo Han Guo Extracts50% Mogroside V
Luo Han Guo Extracts55% Mogroside V

Luo Han Guo Extracts Properties

Mogroside V is a natural cucurbitane glycoside which has a sweetening strength of 250 times that of sucrose and is derived from mature fruit of luo-han-guo (Siraitia grosvenorii, monk fruit).

Mogroside V possesses tumor growth inhibitory activity in in vitro and in vivo models of pancreatic cancer by promoting apoptosis and cell cycle arrest of pancreatic cancer cells (PANC-1 cells),which may in part be mediated through regulating the STAT3 signaling pathway. Mogroside V inhibits the proliferation of pancreatic cancer cells and other tumor cell types in a dose- and time-dependent manner, and shows very little cytotoxicity against the non-tumorigenic epithelial cell line L02. Mogroside V inhibits the downstream targets of the STAT3 pathway that promote cell proliferation (CCND1, CCNE1 and CDK2),while also upregulating cell cycle inhibitors (CDKN1A and CDKN1B)

Mogroside V treatment promotes apoptosis of pancreatic cancer cells in the xenograft tumors. Mogroside V treatment significantly reduces the expression of CD31-labeled blood vessels and of the pro-angiogenic factor vascular endothelial growth factor in the xenografts, indicating that mogroside V might limit the growth of pancreatic tumors by inhibiting angiogenesis and reducing vascular density. Mogroside V treatment inhibits tumor cell growth, induces apoptosis and causes tumor regression

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