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Riboflavin sodium phosphate

130-40-5

C17H20N4NaO9P

478.33

Riboflavin 5′-monophosphate sodium salt, Riboflavin Sodium phosphate

USP/BP/EP

Riboflavin sodium phosphate
ProductSpecifications
Riboflavin sodium phosphateUSP
Riboflavin sodium phosphateBP
Riboflavin sodium phosphateEP

The most reputable manufacturers worldwide

guangji

GUANGJI / China

basf

BASF / German

dsm

DSM / Nederland

hegno

HEGNO / China

enbei

ENBEI / China

Riboflavin sodium phosphate Properties

Melting point:
>300°C
FEMA 
2976
refractive index 
41 ° (C=1.5, 5mol/L HCl)
storage temp. 
2-8°C
solubility 
H2O: soluble50mg/mL, clear, orange
Water Solubility 
almost transparency
Merck 
14,8201
Stability:
Stable. Incompatible with strong oxidizing agents, reducing agents, bases, calcium, metallic salts. Protect from light, air and moisture.
EPA Substance Registry System
Riboflavin 5'-(dihydrogen phosphate),monosodium salt(130-40-5)

SAFETY

Hazard Codes Xi
Risk Statements 36/38
Safety Statements 22-24/25-37/39-26
WGK Germany 3
3-8-10

Description

Riboflavin-5-phosphate sodium (sodium FMN) consist mainly monosodium salt of Riboflavin 5-phophate (FMN),the 5-monophosphate ester of riboflavin. Riboflavin-5-phosphate sodium is produced by direct reaction of riboflavin with a phosphorylating agent such as phosphorous oxychloride in an organic solvent.
Riboflavin 5-phophate (FMN) is essential as a coenzyme in various enzymic reactions in the body and is therefore used in the form of its salts, especially in the form of sodium FMN, as additive to drugs and human and animal food. Sodium FMN is also used as starting material for flavin adenine dinucleotide which is employed for treating vitamin B2 deficiency. It is used as a yellow food color additive (E106).  Riboflavin 5-phosphate sodium is fairly stable in air but is hygroscopic and sensitive to heat and light. The product may be stored for 33 months from the date of manufacture in the unopened original container and at a temperature below 15 °C.

References

[1] https://en.wikipedia.org/wiki/Flavin_mononucleotide
[2] Scientific Opinion on the re-evaluation of riboflavin (E101(i)) and riboflavin-5'-phosphate sodium (E 101(ii)) as food additives, EFSA Journal 2013
[3] Patent US 5095115A: Preparation of riboflavin 5'-phosphate (fmn) and its sodium salt in a lactone

Chemical Properties

solid

Uses

One of the bioactive forms of Riboflavin. Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, leafy vegetables. Richest natural source is yeast. Minute amounts present in all plant and animal cells. Vitamin (enzyme cofactor).

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